ABSTRACT
The inflammatory bowel diseases ulcerative colitis and Crohnïs disease are probably syndromes rather than single entities. Neither the susceptibility genes no definite environmental factors have been found thus far. The immune concept of these disorders might not include all patients, alternative hypotheses for etiology and pathophysiology need to be studied. Consequently non immune based new approaches on alternative etiological/pathophysiological pathways may be necessary
Subject(s)
Humans , Colitis, Ulcerative/physiopathology , Crohn Disease/physiopathology , Colitis, Ulcerative/drug therapy , Colitis, Ulcerative/etiology , Crohn Disease/drug therapy , Crohn Disease/etiology , Cytochrome P-450 Enzyme System/therapeutic use , Cytokines/therapeutic use , Probiotics/therapeutic useABSTRACT
Este estudo com a nefazodona, um novo inibidor seletivo de recaptaçäo de serotonina(ISRS), tem o objetivo maior de mostrar o perfil de interaçöes medicamentosas, droga com droga, assim como com o CYP-450, mostrando os principais efeitos colaterais e açöes terapêuticas principais